stage de M2 à Montpellier portant sur la reconstruction de systèmes dynamiques à partir de données biologiques.

Machine Learning for Cell Dynamics In biomedicine, single-cell RNA sequencing (scRNA-seq) measures the activity of thousands of genes in individual cells, producing high-dimensional datasets that capture cellular diversity and transitions between cell states. In this internship we aim to reconstruct a dynamical system from noisy snapshots of thousands of genes, when the underlying biological processes are only partially observed. The challenge is to compress these data into a low-dimensional representation while preserving the structure of cell-state transitions, infer the stochastic dynamics governing these transitions, and identify a small set of variables and interactions that explain the observed behaviour. This requires going beyond standard prediction methods to build models that are both interpretable and capable of predicting responses to perturbations. The internship will develop machine-learning methods based on variational autoencoders (VAEs), combining deep learning, probabilistic modelling and dynamical systems. Applications include cell differentiation and glioma progression, with the goal of understanding how cells switch between states and how these transitions change during tumour progression and treatment resistance. Details about this internship are available upon request. Host team — LPHI, University of Montpellier, CNRS, INSERM An interdisciplinary team specialising in multiscale dynamical modelling of biological systems (deterministic and probabilistic approaches), machine learning and artificial intelligence. Partner team — IGF, Montpellier A team specialising in gliomas, combining clinical data from neurosurgery (Prof. Hugues Duffau) with multi-omics data and molecular neuroscience research (Prof. Jean-Philippe Hugnot). Location: LPHI, University of Montpellier, CNRS, INSERM, Montpellier, France Profile: Students in applied mathematics, computer science, machine learning or related fields. Application: Send your CV and academic transcripts to ovidiu.radulescu@umontpellier.fr Deadline: 15 November 2026. -- Prof. Ovidiu Radulescu University of Montpellier Laboratory of Pathogens and Host Immunity Leader, Computational Systems Biology team ------------------------------------------------------------------------ LPHI - UMR 5294 CNRS/UM/INSERM Phone: +33-(0)4-6714-9221 Pl. E. Bataillon - Bat. 24 Fax: +33-(0)4-6714-4286 Université de Montpellier email: ovidiu.radulescu@umontpellier.fr CP 107 34095 Montpellier Cedex 5 FRANCE